Metabolic Basis of Primary Hypercholesterolemia
نویسنده
چکیده
Background. Hypercholesterolemia is a well-established risk factor for coronary heart disease. However, the mechanisms underlying hypercholesterolemia, elevated low density lipoprotein (LDL) in particular, are not well understood. To determine these mechanisms, we studied LDL kinetics in a group of men with primary hypercholesterolemia. Methods and Results. LDL kinetics in 134 middle-aged men with high-risk levels of LDL cholesterol (more than 160 mg/dl) were compared with kinetics in 16 men with borderline high-risk levels of LDL cholesterol (120-159 mg/dl) and 14 men with heterozygous familial hypercholesterolemia (FH). Patients with primary hypercholesterolemia (non-FH) were further divided into moderate hypercholesterolemia (LDL cholesterol, 160-210 mg/dl; n=108) and
منابع مشابه
Evaluation of relation between cardiovascular risk factors and osteoarthritis: Results of a cross-sectional Study
Background: The present study conducted to evaluate the frequency of cardiovascular risk factors in patients with osteoarthritis compared to those without osteoarthritis. Materials and Methods: A cross-sectional study was conducted in a university-affiliated hospital in 2017. Using the convenience sampling method, 100 patients based on their symptoms, physical examination and radiographic findi...
متن کاملIdentification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks
Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitativ...
متن کاملA Marker of Disease Severity?
Over the last 2 decades, major advances have been made in our identification and understanding of the genetic basis of cardiovascular disease. More than 40 cardiovascular disorders have now been identified to be directly caused by single-gene defects. These disorders span all aspects of cardiovascular disease and affect all parts of the heart structure. They include the inherited cardiomyopathi...
متن کاملMultiple mutations in genetic cardiovascular disease: a marker of disease severity?
Over the last 2 decades, major advances have been made in our identification and understanding of the genetic basis of cardiovascular disease. More than 40 cardiovascular disorders have now been identified to be directly caused by single-gene defects. These disorders span all aspects of cardiovascular disease and affect all parts of the heart structure. They include the inherited cardiomyopathi...
متن کاملInteractive effect of exercise and Anvillea garcinii extract on cholesterol and thyroid hormones in hypercholesterolemia rats
Introduction: Thyroid hormones are one of the most important hormones affecting the bodychr('39')s metabolic function, so the treatment of hormonal disorders of this gland using low-risk drugs and methods such as exercise and herbal remedies is effective. Hence, the purpose of this study was to evaluate the effect. Interactive exercise and aniseed extract of Anvillea garcinii extract on Cholest...
متن کامل